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EBioMedicine. 2017 Jul;21:14-20. doi: 10.1016/j.ebiom.2017.03.027. Epub 2017 Mar 21.

Telomeres and Cell Senescence - Size Matters Not.

Author information

1
Institute for Cell and Molecular Biosciences, Newcastle University Institute for Ageing, Newcastle upon Tyne NE4 5PL, UK. Electronic address: s.g.victorelli@ncl.ac.uk.
2
Institute for Cell and Molecular Biosciences, Newcastle University Institute for Ageing, Newcastle upon Tyne NE4 5PL, UK.

Abstract

Telomeres are protective structures present at the ends of linear chromosomes that are important in preventing genome instability. Telomeres shorten as a result of cellular replication, leading to a permanent cell cycle arrest, also known as replicative senescence. Senescent cells have been shown to accumulate in mammalian tissue with age and in a number of age-related diseases, suggesting that they might contribute to the loss of tissue function observed with age. In this review, we will first describe evidence suggesting a key role for senescence in the ageing process and elaborate on some of the mechanisms by which telomeres can induce cellular senescence. Furthermore, we will present multiple lines of evidence suggesting that telomeres can act as sensors of both intrinsic and extrinsic stress as well as recent data indicating that telomere-induced senescence may occur irrespectively of the length of telomeres.

KEYWORDS:

Ageing; DNA damage; Senescence; Stress; Telomeres

PMID:
28347656
PMCID:
PMC5514392
DOI:
10.1016/j.ebiom.2017.03.027
[Indexed for MEDLINE]
Free PMC Article

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