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J Cereb Blood Flow Metab. 2018 Sep;38(9):1517-1532. doi: 10.1177/0271678X17700666. Epub 2017 Mar 27.

Infarct topography and functional outcomes.

Author information

1
1 Harvard Medical School, Boston, MA, USA.
2
2 Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
3
3 Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.

Abstract

Acute ischemic stroke represents a major cause of long-term adult disability. Accurate prognostication of post-stroke functional outcomes is invaluable in guiding patient care, targeting early rehabilitation efforts, selecting patients for clinical research, and conveying realistic expectations to families. The involvement of specific brain regions by acute ischemia can alter post-stroke recovery potential. Understanding the influences of infarct topography on neurologic outcomes holds significant promise in prognosis of functional recovery. In this review, we discuss the recent evidence of the contribution of infarct location to patient management decisions and functional outcomes after acute ischemic stroke.

KEYWORDS:

Acute ischemic stroke; neuroimaging; outcomes; topography; voxel-based lesion symptom mapping

PMID:
28345373
PMCID:
PMC6125960
[Available on 2019-09-01]
DOI:
10.1177/0271678X17700666

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