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Liver Int. 2017 Jul;37(7):968-973. doi: 10.1111/liv.13430. Epub 2017 Apr 27.

Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice.

Author information

1
Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
2
Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Abstract

BACKGROUND & AIMS:

Inflammation and impaired hepatocyte regeneration contribute to liver failure in alcoholic hepatitis (AH). Interleukin (IL)-1 is a key inflammatory cytokine in the pathobiology of AH. The role of IL-1 in liver regeneration in the recovery phase of alcohol-induced liver injury is unknown.

METHODS:

In this study, we tested IL-1 receptor antagonist to block IL-1 signalling in a mouse model of acute-on-chronic liver injury on liver inflammation and hepatocyte regeneration in AH.

RESULTS:

We observed that inhibition of IL-1 signalling decreased liver inflammation and neutrophil infiltration, and resulted in enhanced regeneration of hepatocytes and increased rate of recovery from liver injury in AH.

CONCLUSION:

Our novel findings suggest that IL-1 drives sustained liver inflammation and impaired hepatocyte regeneration even after cessation of ethanol exposure.

KEYWORDS:

alcoholic liver disease; interleukin 1; interleukin 1 receptor antagonist; liver regeneration

PMID:
28345165
PMCID:
PMC5479767
DOI:
10.1111/liv.13430
[Indexed for MEDLINE]
Free PMC Article

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