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Future Sci OA. 2016 Dec 13;3(1):FSO164. doi: 10.4155/fsoa-2016-0077. eCollection 2017.

Perinatal high methyl donor alters gene expression in IGF system in male offspring without altering DNA methylation.

Author information

UMR PHAN, INRA, Université de Nantes, 44000 Nantes, France.



To investigate the effect of a protein restriction and a supplementation with methyl donor nutrients during fetal and early postnatal life on the expression and epigenetic state of imprinted genes from the IGF system.


Pregnant female rats were fed a protein-restricted diet supplemented or not with methyl donor.


Gene expression of the Igf2, H19, Igf1, Igf2r and Plagl1 genes in the liver of male offspring at birth and weaning was strongly influenced by maternal diet. Whereas the methylation profiles of the Igf2, H19 and Igf2r genes were remarkably stable, DNA methylation of Plagl1 promoter was slightly modified.


DNA methylation of most, but not all, imprinted gene regulatory regions was resistant to methyl group nutritional supply.


DNA methylation; early growth; imprinted genes; methyl donors; nutritional programming; protein restriction

Conflict of interest statement

Financial & competing interests disclosure This work was funded by INRA. F Giudicelli was supported by a grant from INRA and Région Pays de la Loire. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.

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