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Eur J Surg Oncol. 2018 Mar;44(3):316-320. doi: 10.1016/j.ejso.2017.03.002. Epub 2017 Mar 16.

Ethical issues in non-intervention trials for thyroid cancer.

Author information

1
University of Chicago, Chicago, USA. Electronic address: pangelos@surgery.bsd.uchicago.edu.
2
Gustave Roussy, Paris, France.
3
Memorial Sloan Kettering Cancer Center, New York, USA.
4
University of Edinburgh, Edinburgh, UK.
5
Mount Sinai Hospital, New York, USA.
6
University of Udine, Udine, Italy.
7
University of Oviedo, Oviedo, Spain.
8
University of Arizona College of Medicine, Phoenix, USA.
9
International Head and Neck Scientific Group, Italy.

Abstract

In recent years, the increasing numbers of small, apparently indolent thyroid cancers diagnosed in the world have encouraged investigators to consider non-intervention as an alternative to surgical management. In the following pages, the prospect of a non-intervention trial for thyroid cancer is considered with attention to the ethical issues that such a trial might raise. Such a non-intervention trial is analyzed relative to 7 ethical considerations: the social or scientific value of the research, the scientific validity of the trial, the necessity of fair selection of participants, a favorable risk-benefit ratio for trial participants, independent review of the trial, informed consent, and allowing the study participants to withdraw from the trial. A non-intervention trial for thyroid cancer is also considered relative to the central concept of equipoise.

KEYWORDS:

Clinical trials; Equipoise; Ethics; Non-intervention; Research ethics; Thyroid cancer

PMID:
28343732
DOI:
10.1016/j.ejso.2017.03.002
[Indexed for MEDLINE]

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