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Dig Dis Sci. 2017 May;62(5):1155-1164. doi: 10.1007/s10620-017-4538-6. Epub 2017 Mar 24.

Influences of the Gut Microbiota on DNA Methylation and Histone Modification.

Ye J1,2, Wu W1,2, Li Y1,2, Li L3,4.

Author information

1
State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China.
2
Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, 310003, China.
3
State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China. ljli@zju.edu.cn.
4
Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, 310003, China. ljli@zju.edu.cn.

Abstract

The gut microbiota is a vast ensemble of microorganisms inhabiting the mammalian gastrointestinal tract that can impact physiologic and pathologic processes. However, our understanding of the underlying mechanism for the dynamic interaction between host and gut microbiota is still in its infancy. The highly evolved epigenetic modifications allow hosts to reprogram the genome in response to environmental stimuli, which may play a key role in triggering multiple human diseases. In spite of increasing studies in gut microbiota and epigenetic modifications, the correlation between them has not been well elaborated. Here, we review current knowledge of gut microbiota impacts on epigenetic modifications, the major evidence of which centers on DNA methylation and histone modification of the immune system.

KEYWORDS:

DNA methylation; Epigenetic modifications; Gut microbiota; Histone modification

PMID:
28341870
DOI:
10.1007/s10620-017-4538-6
[Indexed for MEDLINE]

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