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Biochim Biophys Acta Gen Subj. 2017 Jul;1861(7):1801-1812. doi: 10.1016/j.bbagen.2017.03.017. Epub 2017 Mar 21.

Modulation of gut microbiota contributes to curcumin-mediated attenuation of hepatic steatosis in rats.

Author information

1
Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, No 321 Zhongshan Road, Nanjing 210008, People's Republic of China.
2
Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, No 321 Zhongshan Road, Nanjing 210008, People's Republic of China. Electronic address: zhudalong@nju.edu.cn.
3
Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, No 321 Zhongshan Road, Nanjing 210008, People's Republic of China. Electronic address: biyan@nju.edu.cn.

Abstract

BACKGROUND:

Structural disruption of gut microbiota contributes to the development of non-alcoholic fatty liver disease (NAFLD) and modulating the gut microbiota represents a novel strategy for NAFLD prevention. Although previous studies have demonstrated that curcumin alleviates hepatic steatosis, its effect on the gut microbiota modulation has not been investigated.

METHODS:

Next generation sequencing and multivariate analysis were utilized to evaluate the structural changes of gut microbiota in a NAFLD rat model induced by high fat-diet (HFD) feeding.

RESULTS:

We found that curcumin attenuated hepatic ectopic fat deposition, improved intestinal barrier integrity, and alleviated metabolic endotoxemia in HFD-fed rats. More importantly, curcumin dramatically shifted the overall structure of the HFD-disrupted gut microbiota toward that of lean rats fed a normal diet and altered the gut microbial composition. The abundances of 110 operational taxonomic units (OTUs) were altered by curcumin. Seventy-six altered OTUs were significantly correlated with one or more hepatic steatosis associated parameters and designated 'functionally relevant phylotypes'. Thirty-six of the 47 functionally relevant OTUs that were positively correlated with hepatic steatosis associated parameters were reduced by curcumin.

CONCLUSION:

These results indicate that curcumin alleviates hepatic steatosis in part through stain-specific impacts on hepatic steatosis associated phylotypes of gut microbiota in rats.

GENERAL SIGNIFICANCE:

Compounds with antimicrobial activities should be further investigated as novel adjunctive therapies for NAFLD.

KEYWORDS:

Curcumin; Gut microbiota; Hepatic steatosis

PMID:
28341485
DOI:
10.1016/j.bbagen.2017.03.017
[Indexed for MEDLINE]

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