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J Am Acad Dermatol. 2017 Jul;77(1):33-41.e1. doi: 10.1016/j.jaad.2017.01.044. Epub 2017 Mar 22.

The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical study.

Author information

1
Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan.
2
Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama.
3
Independent Researcher, Boston, Massachusetts.
4
Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan. Electronic address: ihamzav1@hfhs.org.

Abstract

BACKGROUND:

There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen.

OBJECTIVE:

This study was designed to objectively evaluate the molecular and photobiologic effects of oral administration of Polypodium leucotomos extract (PLE).

METHODS:

In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser). Evaluation was done immediately and 24 hours after irradiation. On days 3 and 4, irradiation and evaluation process was repeated after ingestion of PLE.

RESULTS:

Clinical assessments and colorimetry data showed a decrease in UVB-induced changes in 17 of 22 subjects post-PLE administration; histology findings demonstrated such a decrease in all 22 subjects.

LIMITATIONS:

Only 2 doses of PLE were given. Furthermore, subjects with skin phototypes I to III only were studied.

CONCLUSION:

The results suggest that PLE can potentially be used as an adjunctive agent to lessen the negative photobiologic effects of UVB.

KEYWORDS:

Polypodium leucotomos extract; colorimetry; cyclobutane pyrimidine dimers; excimer laser; minimal erythema dose; sunburn cells; ultraviolet

PMID:
28341348
PMCID:
PMC5730054
DOI:
10.1016/j.jaad.2017.01.044
[Indexed for MEDLINE]
Free PMC Article

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