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Burns. 2017 Mar;43(2):310-317. doi: 10.1016/j.burns.2016.08.032. Epub 2016 Oct 27.

The ability of selected plant essential oils to enhance the action of recommended antibiotics against pathogenic wound bacteria.

Author information

1
Department of Allergology and Respiratory Rehabilitation, 2nd Chair of Otolaryngology, Medical University of Lodz, Poland. Electronic address: monika.sienkiewicz@umed.lodz.pl.
2
Department of Microbiology and Medical Laboratory Immunology, Medical University of Lodz, Poland.
3
Pharmacology and Toxicology Department, Medical University of Lodz, Poland.
4
Pharmaceutical Biotechnology Department, Medical University of Lodz, Poland.
5
Physiotherapy Laboratory, Department of Physical Medicine, Medical University of Lodz, Poland.
6
Department of Otolaryngology and Laryngological Oncology, 2nd Chair of Otolaryngology, Medical University of Lodz, Poland.
7
Department of Allergology and Respiratory Rehabilitation, 2nd Chair of Otolaryngology, Medical University of Lodz, Poland.

Abstract

The aim of this work was to characterize the ability of essential oils to support antibiotics against pathogenic bacteria in wounds. Gram-positive and Gram-negative bacteria obtained from wound infections were identified according to standard microbiological methods. Essential oils were analysed by GC-FID-MS. The susceptibility of bacteria to antibiotics, essential oils and their combination was assessed using the disc-diffusion method. The Minimal Inhibitory Concentration and Minimum Bactericidal Concentration of the essential oils were established by the micro-dilution broth method. Although cinnamon, clove, thyme and lavender essential oils were found to have the greatest antibacterial activity when used alone, the greatest additive and synergistic effects against pathogenic wound bacteria in combination with recommended antibiotics were demonstrated by basil, clary sage and rosemary oils.

KEYWORDS:

Additive effect; Antibiotic resistance; Essential oils; Synergistic effect; Wound pathogens

PMID:
28341256
DOI:
10.1016/j.burns.2016.08.032
[Indexed for MEDLINE]

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