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Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Aug;1862(8):740-746. doi: 10.1016/j.bbalip.2017.03.004. Epub 2017 Mar 22.

Lipidomics: Prospects from a technological perspective.

Author information

1
Center for Medical Research (ZMF), Medical University of Graz, Stiftingtalstrasse 24, 8010 Graz, Austria.
2
Center for Medical Research (ZMF), Medical University of Graz, Stiftingtalstrasse 24, 8010 Graz, Austria; Institute of Molecular Biotechnology, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria; Omics Center Graz, BioTechMed-Graz, Stiftingtalstrasse 24, 8010 Graz, Austria.
3
Center for Medical Research (ZMF), Medical University of Graz, Stiftingtalstrasse 24, 8010 Graz, Austria; Omics Center Graz, BioTechMed-Graz, Stiftingtalstrasse 24, 8010 Graz, Austria. Electronic address: harald.koefeler@medunigraz.at.

Abstract

Over the last two decades, lipidomics has evolved into an 'omics' technology pari passu with benchmarking 'omics' technologies, such as genomics or proteomics. The driving force behind this development was a constant advance in mass spectrometry and related technologies. The aim of this opinion article is to give the interested reader a concise but still comprehensive overview about the technological state of the art in lipidomics, current challenges and perspectives for future development. As such, this article guides through the whole workflow of lipidomics, from sampling to data analysis. This article is part of a Special Issue entitled: BBALIP_Lipidomics Opinion Articles edited by Sepp Kohlwein.

KEYWORDS:

Biomarker discovery; Chromatography; Data processing; Lipid extraction; Lipidomics; Mass spectrometry

PMID:
28341148
PMCID:
PMC6013030
DOI:
10.1016/j.bbalip.2017.03.004
[Indexed for MEDLINE]
Free PMC Article

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