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BMC Public Health. 2017 Mar 24;17(1):279. doi: 10.1186/s12889-017-4181-3.

The singular epidemiology of HPV infection among French Guianese women with normal cytology.

Author information

1
Centre d'Investigation Clinique Antilles-Guyane, CIC INSERM 1424, Centre hospitalier de Cayenne, Rue des flamboyants, 97300, Cayenne, French Guiana.
2
Laboratoire de Virologie, CHU de la Martinique, Fort de France, Martinique.
3
Laboratoire d'anatomopathologie, CHU de la Martinique, Fort de France, Martinique.
4
Service de Gynecologie Obstétrique, Centre hospitalier de Cayenne, Cayenne, French Guiana.
5
AGDOC Association de Dépistage Organisé des Cancers de Guyane, Cayenne, French Guiana.
6
Département des Centres délocalisés de prévention et de soins, Centre Hospitalier de Cayenne, 97300, Cayenne, French Guiana.
7
Service de Gynecologie Obstétrique, Centre Hospitalier de l'Ouest Guyanais, Saint Laurent du Maroni, Cayenne, French Guiana.
8
Laboratoire des interactions virus Hôtes, Institut Pasteur de la Guyane, Cayenne, French Guiana.
9
Centre d'Investigation Clinique Antilles-Guyane, CIC INSERM 1424, Centre hospitalier de Cayenne, Rue des flamboyants, 97300, Cayenne, French Guiana. mathieu.nacher@ch-cayenne.fr.

Abstract

BACKGROUND:

In French Guiana, cervical cancer is the second most frequent cancer in females. The objective of the present study was to describe the prevalence of HPV infections in women with normal cervical cytology living in the remote villages of French Guiana.

METHODS:

Before the study, the study team communicated in the remote villages on the importance of screening. All women from the target population were offered to participate. They signed informed consent during inclusion and then had a concomitant HPV-test and cervical smear. Only women with normal cytology and a good quality smear were analyzed. The detection of HPV-DNA was performed using the GREINER-BIO-ONE kit.

RESULTS:

Overall, 27.2% of women with normal cervical cytology had a positive HPV-test. There was a U-shaped evolution of prevalence with women over 50 years having the highest HPV prevalence, followed by the 20 to 29 years group. The most prevalent HPV genotypes were HPV 53(3.52%), 68(3.33%), 52(2.59%), 31(2.22%) and 16 (1.85%). The proportion of HPV 16 among HPV-infected women was 6.8%.

CONCLUSIONS:

HPV prevalence in cytologically normal women was very high. The most prevalent genotypes were very different from what is usually described in the world, and notably in South America.

KEYWORDS:

French Guiana; Genotype; Human papillomavirus; Normal cytology; Prevalence

PMID:
28340612
PMCID:
PMC5366144
DOI:
10.1186/s12889-017-4181-3
[Indexed for MEDLINE]
Free PMC Article

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