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Clin Neurophysiol. 2017 May;128(5):830-838. doi: 10.1016/j.clinph.2017.02.018. Epub 2017 Mar 4.

Reorganization of anterior and posterior hippocampal networks associated with memory performance in mesial temporal lobe epilepsy.

Author information

1
Department of Radiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, China.
2
Department of Neurology, Epilepsy Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, China.
3
Department of Neurology, Epilepsy Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, China; Department of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China and Zhejiang Province Key Laboratory of Neurobiology, College of Pharmaceutical Sciences, Zhejiang University, China.
4
Department of Radiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, China. Electronic address: zhangminming@zju.edu.cn.
5
Department of Neurology, Epilepsy Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, China; Department of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China and Zhejiang Province Key Laboratory of Neurobiology, College of Pharmaceutical Sciences, Zhejiang University, China. Electronic address: shuangwang1977@gmail.com.

Abstract

OBJECTIVE:

To investigate the pattern of functional demarcation of hippocampal network and its relationship with memory performance in mesial temporal lobe epilepsy (mTLE) with unilateral hippocampal sclerosis.

METHODS:

Resting state fMRI data were acquired from fifteen left mTLE patients, fourteen right mTLE patients and twenty healthy subjects. We explore the hippocampal-cortical alterations and corresponding inter-hemispheric functional connectivity (FC) across anterior and posterior hippocampal networks. The association between FC and memory performance was assessed.

RESULTS:

Left mTLE showed increased intra-hemispheric FC in anterior hippocampal networks, including left anterior hippocampal-entorhinal cortex and right anterior hippocampal-orbitofrontal cortex, and decreased inter-hemispheric FC between anterior hippocampus, entorhinal cortex and posterior cingulate cortex. Right mTLE was associated with extensive reduction in inter-hemispheric FC along the areas of anterior and posterior hippocampal networks. Intra-hemispheric FC between left anterior hippocampus and entorhinal cortex was positively correlated with verbal memory in left mTLE. Inter-hemispheric FC between posterior parahippocampal gyrus was negatively correlated with verbal memory in right mTLE.

CONCLUSIONS:

Our findings suggested that left and right mTLE exhibit different neural reorganization patterns of anterior and posterior hippocampal networks associated with verbal memory.

SIGNIFICANCE:

The findings may facilitate the characterization of mTLE associated with memory deficit.

KEYWORDS:

Brain plasticity; Memory; Mesial temporal lobe epilepsy; fMRI

PMID:
28340432
DOI:
10.1016/j.clinph.2017.02.018
[Indexed for MEDLINE]

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