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Cell. 2017 Mar 23;169(1):1-3. doi: 10.1016/j.cell.2017.03.018.

Experimental Evolution to Study Virus Emergence.

Author information

1
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: grubaugh@scripps.edu.
2
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Scripps Translational Science Institute, La Jolla, CA 92037, USA. Electronic address: andersen@scripps.edu.

Abstract

Understanding how viruses adapt to new environments and acquire new phenotypes is critical for developing comprehensive responses to outbreaks. By studying the emergence of vaccine-derived poliovirus outbreaks, Stern et al. describe how a combination of sequence analysis and experimental evolution can be used to reveal adaptive pathways.

PMID:
28340335
DOI:
10.1016/j.cell.2017.03.018
[Indexed for MEDLINE]
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