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Vox Sang. 2017 Jul;112(5):469-472. doi: 10.1111/vox.12515. Epub 2017 Mar 23.

A novel network analysis tool to identify relationships between disease states and risks for red blood cell alloimmunization.

Author information

1
Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.
2
Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
3
Pathology & Laboratory Medicine Service, VA Connecticut Healthcare System, West Haven, CT, USA.

Abstract

We hypothesized that diagnoses may be associated with alloantibody 'responder' status and examined associations between disease states and alloimmunization. Patients with ≥1 alloantibody and non-alloimmunized controls were analysed. Pearson's coefficients were calculated to determine associations between alloimmunization and diseases; significant correlations were selected to construct a network. Inflammatory disorders and diseases requiring chronic transfusion support were associated with responder status. Mitigation steps may be considered in patients with these disorders.

KEYWORDS:

RBC antibodies; alloimmunization; immunohaematology

PMID:
28337751
DOI:
10.1111/vox.12515
[Indexed for MEDLINE]

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