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Arch Gynecol Obstet. 2017 May;295(5):1157-1165. doi: 10.1007/s00404-017-4338-4. Epub 2017 Mar 23.

First trimester TTR-RBP4-ROH complex and angiogenic factors in the prediction of small for gestational age infant's outcome.

Author information

1
Obstetrics and Gynecology, St. Franziskus-Hospital of Ahlen, Robert-Koch-Straße 55, 59227, Ahlen, Germany. fruscal@libero.it.
2
Obstetrics and Gynecology, University Hospital of Münster, Münster, Germany. fruscal@libero.it.
3
Obstetrics and Gynecology, University Hospital of Münster, Münster, Germany.
4
Obstetrics and Gynecology, DISM, AOU "SM della Misericordia" of Udine, Udine, Italy.
5
Clinic of Obstetrics and Gynecology, Monfalcone, Italy.
6
Department of Physiology and Pathophysiology, Institute of Nutritional Science, University of Potsdam, Potsdam, Germany.
7
Centrum für Laboratoriumsmedizin, University Hospital of Münster, Münster, Germany.
8
Department of Fetal Cardiology, Herz-und Diabetes Zentrum NRW, Bad Oeynhausen, Germany.
9
Center for Prenatal Medicine und Human Genetic, Münster, Germany.

Abstract

PURPOSE:

To study the role of the TTR-RBP4-ROH complex components (transthyretin, serum retinol binding protein, retinol) and of angiogenic factors PlGF (placental growth factor) and sFlt-1 (soluble fms-like tyrosine kinase-1) in pregnancies complicated by small for gestational age infants (SGA).

METHODS:

Case control study conducted on maternal serum collected between 11 + 0 to 13 + 6 weeks of gestation. TTR, RBP4, ROH, PlGF and sFlt-1 were measured in SGA patients (birth weight <10%) who delivered at term (n = 37) and before 37 weeks of gestation (n = 17) and in a matched control group with uneventful pregnancies (n = 37).

RESULTS:

We found decreased RBP4 in SGA patients that delivered fetuses <3% and in fetuses delivered after the 37 weeks of gestation compared to controls [1.50 (95% CI 1.40-1.75) vs 1.62 (95% CI 1.47-1.98), p < 0.05]. Further, we found lower PlGF and sFlt-1 concentrations in SGA that delivered before 37 weeks of gestation compared to controls (respectively, PIGF and sFlt-1: 39.7 pg/ml (95% CI 32.3-66.3) vs 62.9 pg/ml (95% CI 45.2-78.4) and 906 pg/ml (95% CI 727-1626) vs 1610 pg/ml (95% CI 1088-212), p < 0.05).

CONCLUSIONS:

First trimester maternal serum RBP4 and angiogenic factors PlGF and sFlt-1 can differently predict the timing of delivery of pregnancies complicated by SGA fetuses.

KEYWORDS:

First trimester; Low birth weight; Marker; PlGF; Pregnancy; RBP4; Retinol; Small for gestational age; TTR; Vitamin A; sFlt-1

PMID:
28337595
DOI:
10.1007/s00404-017-4338-4
[Indexed for MEDLINE]

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