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Neuroimage Clin. 2016 Dec 10;14:286-297. doi: 10.1016/j.nicl.2016.12.006. eCollection 2017.

Network degeneration and dysfunction in presymptomatic C9ORF72 expansion carriers.

Author information

1
University of California, San Francisco, Memory and Aging Center, Department of Neurology, 675 Nelson Rising Lane, MC:1207, San Francisco, CA 94158, USA.
2
University of California, San Francisco, Memory and Aging Center, Department of Neurology, 675 Nelson Rising Lane, MC:1207, San Francisco, CA 94158, USA; Stanford University, Department of Psychology, Jordan Hall, 450 Serra Mall, Stanford, CA 94305, USA.
3
University of California, San Francisco, Department of Neurology, 675 Nelson Rising Lane, MC: 0444, San Francisco, CA 94158, USA.
4
Department of Neurology and Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, 760 Westwood Plaza Los Angeles, CA 90024, USA.
5
Mayo Clinic, Department of Neuroscience, Birdsall Research Building 207, 4500 San Pablo Road, Jacksonville, FL 32224, USA.
6
University of California, San Francisco, Memory and Aging Center, Department of Neurology, 675 Nelson Rising Lane, MC:1207, San Francisco, CA 94158, USA; University of California, San Francisco, Department of Pathology, 675 Nelson Rising Lane, Suite 140, MC:1207, San Francisco, CA 94158, USA.

Abstract

Hexanucleotide repeat expansions in C9ORF72 are the most common known genetic cause of familial and sporadic frontotemporal dementia and amyotrophic lateral sclerosis. Previous work has shown that patients with behavioral variant frontotemporal dementia due to C9ORF72 show salience and sensorimotor network disruptions comparable to those seen in sporadic behavioral variant frontotemporal dementia, but it remains unknown how early in the lifespan these and other changes in brain structure and function arise. To gain insights into this question, we compared 15 presymptomatic carriers (age 43.7 ± 10.2 years, nine females) to matched healthy controls. We used voxel-based morphometry to assess gray matter, diffusion tensor imaging to interrogate white matter tracts, and task-free functional MRI to probe the salience, sensorimotor, default mode, and medial pulvinar thalamus-seeded networks. We further used a retrospective chart review to ascertain psychiatric histories in carriers and their non-carrier family members. Carriers showed normal cognition and behavior despite gray matter volume and brain connectivity deficits that were apparent as early as the fourth decade of life. Gray matter volume deficits were topographically similar though less severe than those in patients with behavioral variant frontotemporal dementia due to C9ORF72, with major foci in cingulate, insula, thalamus, and striatum. Reduced white matter integrity was found in the corpus callosum, cingulum bundles, corticospinal tracts, uncinate fasciculi and inferior longitudinal fasciculi. Intrinsic connectivity deficits were detected in all four networks but most prominent in salience and medial pulvinar thalamus-seeded networks. Carrier and control groups showed comparable relationships between imaging metrics and age, suggesting that deficits emerge during early adulthood. Carriers and non-carrier family members had comparable lifetime histories of psychiatric symptoms. Taken together, the findings suggest that presymptomatic C9ORF72 expansion carriers exhibit functionally compensated brain volume and connectivity deficits that are similar, though less severe, to those reported during the symptomatic phase. The early adulthood emergence of these deficits suggests that they represent aberrant network patterning during development, an early neurodegeneration prodrome, or both.

KEYWORDS:

ALS, amyotrophic lateral sclerosis; Amyotrophic lateral sclerosis; CDR, Clinical Dementia Rating scale; DMN, default mode network; Diffusion tensor imaging; FA, fractional anisotropy; FTD, frontotemporal dementia; FWE, familywise error; Frontotemporal dementia; Functional MRI; Genetics; HC, healthy control; ICN, intrinsic connectivity network; IRI, Interpersonal Reactivity Index; MMSE, Mini-Mental State Exam; MND, motor neuron disease; NPI, Neuropsychiatric Inventory; ROI, region of interest; SMN, sensorimotor network; TIV, total intracranial volume; VBM, voxel-based morphometry; bvFTD, behavioral variant frontotemporal dementia; fMRI, functional MRI; preSxC9, presymptomatic C9ORF72 expansion carriers

PMID:
28337409
PMCID:
PMC5349617
DOI:
10.1016/j.nicl.2016.12.006
[Indexed for MEDLINE]
Free PMC Article

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