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Infect Genet Evol. 2017 Jul;51:86-88. doi: 10.1016/j.meegid.2017.03.020. Epub 2017 Mar 20.

Emergence of norovirus GII.2 and its novel recombination during the gastroenteritis outbreak in Japanese children in mid-2016.

Author information

1
Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan.
2
Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan; Department of Developmental Medical Sciences, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
3
Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
4
Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan; Department of Developmental Medical Sciences, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address: ushijima-hiroshi@jcom.home.ne.jp.

Abstract

In mid-2016, norovirus GII.2 emerged as a major cause of gastroenteritis outbreak in Japan with overall detection rate of 56.3% of norovirus cases. The differences in ORF1 and ORF2 of some norovirus GII were observed. Inter-subtype recombinants GII.Pe/GII.2, GII.P16/GII.2 and GII.P17/GII.2 were detected. Three amino acid substitutions were noted at P2 antigenic site of GII.P16/GII.2 recombinants. Furthermore, this study revealed that the current immunochromatographic kit available in Japan could be used effectively for the detection of recent GII.2 genotype.

KEYWORDS:

Gastroenteritis; Japan; Norovirus; Outbreak; Recombinant

PMID:
28336428
DOI:
10.1016/j.meegid.2017.03.020
[Indexed for MEDLINE]

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