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Exp Cell Res. 2017 Jul 15;356(2):128-135. doi: 10.1016/j.yexcr.2017.03.041. Epub 2017 Mar 20.

A compendium of proteins that interact with HIF-1α.

Author information

1
Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205 USA. Electronic address: gsemenza@jhmi.edu.

Abstract

Hypoxia-inducible factor 1 (HIF-1) is the founding member of a family of transcription factors that function as master regulators of oxygen homeostasis. HIF-1 is composed of an O2-regulated HIF-1α subunit and a constitutively expressed HIF-1β subunit. This review provides a compendium of proteins that interact with the HIF-1α subunit, many of which regulate HIF-1 activity in either an O2-dependent or O2-independent manner.

KEYWORDS:

Oxygen biology; Transcriptional regulation

PMID:
28336293
PMCID:
PMC5541399
DOI:
10.1016/j.yexcr.2017.03.041
[Indexed for MEDLINE]
Free PMC Article

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