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J Perinatol. 2017 Jun;37(6):673-678. doi: 10.1038/jp.2017.18. Epub 2017 Mar 23.

Maternal/neonatal vitamin D deficiency: a new risk factor for necrotizing enterocolitis in preterm infants?

Author information

1
Department of Neonatology, Kanuni Sultan Suleyman Teaching and Research Hospital, Istanbul, Turkey.
2
Faculty of Medicine, Department of Neonatology, Maltepe University, Istanbul, Turkey.

Abstract

OBJECTIVE:

The objective of the study was to investigate the possible association between maternal/neonatal 25-hydroxy vitamin D (25-OHD) levels and development of necrotizing enterocolitis (NEC).

STUDY DESIGN:

One hundred and forty-five preterm infants ⩽36 weeks of gestation were enrolled. 25-OHD levels were determined in maternal/neonatal blood samples that were obtained at the time of admission to the neonatal intensive care unit.

RESULTS:

Of the 145 enrolled patients, 26 (18%) developed NEC. Maternal/neonatal 25-OHD levels in the NEC group were significantly lower than those of the no-NEC group (P=0.001 and 0.004, respectively). In univariate logistic regression analysis, both maternal/neonatal vitamin D levels were a significant predictor of NEC (odds ratio (OR): 0.92 and 0.89; P<0.001 and P<0.005, respectively). However, multivariate logistic regression analysis revealed that only maternal vitamin D level was a significant predictor of NEC (OR: 0.86, P<0.0009).

CONCLUSION:

This is the first study to propose a possible association between maternal/neonatal 25-OHD levels and subsequent development of NEC in preterm infants.

PMID:
28333154
DOI:
10.1038/jp.2017.18
[Indexed for MEDLINE]

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