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J Cell Biol. 2017 Apr 3;216(4):871-873. doi: 10.1083/jcb.201702028. Epub 2017 Mar 22.

Macrophages: micromanagers of antagonistic signaling nanoclusters.

Author information

1
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS Oxford, England, UK christian.eggeling@rdm.ox.ac.uk.
2
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS Oxford, England, UK.

Abstract

How cells integrate antagonistic receptor signaling events is enigmatic. Using superresolution optical microscopy, Lopes et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608094) demonstrate the nanometer-scale molecular reorganization of antagonistic signaling receptors in macrophages, after engagement by the receptors of activating and inhibitory ligands. They propose that large-scale rearrangements of this type underpin decision-making by these cells.

PMID:
28330938
PMCID:
PMC5379961
DOI:
10.1083/jcb.201702028
[Indexed for MEDLINE]
Free PMC Article

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