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Spectrochim Acta A Mol Biomol Spectrosc. 2017 Jun 15;181:47-54. doi: 10.1016/j.saa.2017.03.032. Epub 2017 Mar 16.

Antibacterial properties of amino acid functionalized silver nanoparticles decorated on graphene oxide sheets.

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School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur 492010, (C.G.), India.
Department of Chemistry, Govt. Madhav Science P. G. College, Ujjain 456010, (M.P.), India.
School of Studies in Biotechnology, Pt. Ravishankar Shukla University, Raipur 492010, (C.G.), India.
School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur 492010, (C.G.), India. Electronic address:


Graphene oxide (GO) sheets decorated with amino acid L-cysteine (L-cys) functionalized silver nanoparticles (GO-L-cys-Ag) was synthesized by AgNO3, trisodium citrate, and NaBH4. GO-L-cys-Ag nanocomposite was characterized by transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectra, ultraviolet-visible (UV-vis) absorption spectra, which demonstrated that a diameter of L-cys-AgNPs compactly deposited on GO. Antibacterial activity tests of GO-L-cys-Ag nanocomposite were carried out using Escherichia coli MTCC 1687 and Staphylococcus aureus MTCC 3160 as model strains of Gram-negative and Gram-positive bacteria, respectively. The effect of bactericide dosage on antibacterial activity of GO-L-cys-Ag nanocomposite was examined by plate count, well diffusion and broth dilution methods. Morphological observation of bacterial cells by scanning electron microscope (SEM) showed that GO-L-cys-Ag nanocomposite was more destructive to cell membrane of Escherichia coli than that of Staphylococcus aureus. The above technique establish that the bactericidal property of GO-L-cys-Ag nanocomposite with wide range of applications in biomedical science.


Antibacterial activity; GO-L-cys-Ag nanocomposite; Graphene oxide; L-cys-AgNPs; SEM

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