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Science. 1988 Apr 1;240(4848):80-2.

Biologic features of HIV-1 that correlate with virulence in the host.

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  • 1Department of Medicine, University of California, School of Medicine, San Francisco 94143.

Abstract

Individuals infected with the human immunodeficiency virus type 1 (HIV-1) may be asymptomatic or have AIDS-related complex or the acquired immuno deficiency syndrome (AIDS). Little is known about the factors that influence progression of infection to AIDS. In this study of isolates of HIV-1 obtained at intervals during the infection of four individuals, the development of disease was found to be correlated with the emergence of HIV-1 variants that were more cytopathic in vitro as the disease progressed and that replicated more efficiently in a wide variety of different human cells. The biologic properties of HIV-1 in vitro thus appear to reflect its virulence in the host. Further studies of such sequentially isolated viruses may lead to the identification of viral genes that govern pathogenesis.

PMID:
2832945
[PubMed - indexed for MEDLINE]
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