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Clin Infect Dis. 2017 Apr 15;64(8):1129-1132. doi: 10.1093/cid/cix046.

Pertussis Antibody Transfer to Preterm Neonates After Second- Versus Third-Trimester Maternal Immunization.

Author information

1
Center for Vaccinology and Neonatal Immunology, Department of Pathology-Immunology, University of Geneva, Switzerland.
2
Department of Neonatology and Pediatric Intensive Care, Children's Hospital of Geneva, Switzerland.
3
Department of Pediatrics, Children's Hospital of Geneva, Switzerland.
4
Clinical Research Center, , University of Geneva, Switzerland.
5
Department of Gynecology and Obstetrics, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Switzerland.
6
BioNet-Asia Co, Ltd, Bangkok, Thailand.

Abstract

Preterm infants are most vulnerable to pertussis. Whether they might benefit from maternal immunization is unknown. Extending our previous results in term neonates, this observational study demonstrates that second- rather than third-trimester maternal vaccination results in higher birth anti-pertussis toxin titers in preterm neonates.

KEYWORDS:

maternal antibodies; maternal immunization; neonates; pertussis; preterm

PMID:
28329335
PMCID:
PMC5439344
DOI:
10.1093/cid/cix046
[Indexed for MEDLINE]
Free PMC Article

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