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Clin Infect Dis. 2017 Jun 1;64(11):1612-1614. doi: 10.1093/cid/cix176.

Impact of Medication Adherence on Virologic Failure in A5202: A Randomized, Partially Blinded, Phase 3B Study.

Parker RA1,2,3,4, Rabideau DJ1, Sax PE3,5, Tierney C6, Daar ES7,8, Collier AC9, Losina E2,3,4,10,11,12, Freedberg KA2,3,4,11,13,14.

Author information

1
Biostatistics Center, and.
2
Medical Practice Evaluation Center, Massachusetts General Hospital.
3
Harvard Medical School.
4
Harvard University Center for AIDS Research.
5
Division of Infectious Diseases, Brigham and Women's Hospital, and.
6
Center for Biostatistics in AIDS Research in the Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
7
Division of HIV Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, and.
8
David Geffen School of Medicine at UCLA, Los Angeles, California.
9
Division of Allergy and Infectious Diseases, University of Washington, Seattle; and.
10
Department of Orthopedic Surgery, Brigham and Women's Hospital.
11
Department of Epidemiology, Boston University School of Public Health.
12
Department of Biostatistics, Boston University School of Public Health.
13
Divisions of General Internal Medicine and Infectious Diseases, Massachusetts General Hospital, and.
14
Department of Health Policy and Management, Harvard School of Public Health, Boston, Massachusetts.

Abstract

In AIDS Clinical Trials Group A5202, participants who reported missing their medication within the past month or not providing adherence reports at both 8 and 24 weeks had 5 times the hazard of virological failure compared to more adherent participants. Adherence interventions should focus on such patients.

KEYWORDS:

HIV; adherence; missing medication; self-report; virologic failure.

PMID:
28329243
PMCID:
PMC5434358
DOI:
10.1093/cid/cix176
[Indexed for MEDLINE]
Free PMC Article

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