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Lab Anim (NY). 2017 Mar 22;46(4):114-122. doi: 10.1038/laban.1222.

Microbiota and reproducibility of rodent models.

Author information

1
Department of Veterinary Pathobiology at the University of Missouri in Columbia, Missouri.

Abstract

The gut microbiota (GM) plays a critical role in human health and disease. Likewise, it is becoming increasingly evident that changes or disruptions to the GM can have significant effects on animal models and their expressed phenotypes, adding a complex and important variable into basic research and preclinical studies. In this article, we review some of the most common sources of GM variability in rodent models, and discuss measures to address this variability for improved reproducibility.

PMID:
28328896
PMCID:
PMC5762113
DOI:
10.1038/laban.1222
[Indexed for MEDLINE]
Free PMC Article

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