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BMC Nephrol. 2017 Mar 21;18(1):98. doi: 10.1186/s12882-017-0509-6.

Higher plasma transforming growth factor (TGF)-β is associated with kidney disease in older community dwelling adults.

Author information

1
University of Colorado Anschutz Medical Center, Aurora, USA.
2
University of Washington, Seattle, USA.
3
Albert Einstein College of Medicine, New York, USA.
4
Brigham and Women's Hospital and Harvard Medical School, Boston, USA.
5
Beth Israel Deaconess Medical Center, Boston, USA.
6
University of California San Francisco School of Medicine, San Francisco, USA.
7
University of California, San Diego, USA.
8
University of Colorado Anschutz Medical Center, Aurora, USA. diana.jalal@ucdenver.edu.
9
Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Campus Stop: C281, 12700 E. 19th Ave, Aurora, CO, 80015, USA. diana.jalal@ucdenver.edu.

Abstract

BACKGROUND:

TGF-β is induced in the vasculature with aging suggesting that high plasma TGF-β levels may be a risk factor for chronic kidney disease (CKD) in older adults.

METHODS:

We conducted a cross-sectional analysis of the association between plasma TGF-β levels and CKD including data for 1722 older adults who had participated in the 1996/97 visit of the Cardiovascular Health Study (CHS). Prevalent CKD was defined as eGFR < 60 mL/min/1.73 m2 or urinary albumin/creatinine ratio (ACR) ≥30 mg/g. We also evaluated whether baseline TGF-β levels predicted change in eGFR, cardiovascular (CV) events, or mortality in longitudinal analysis.

RESULTS:

Plasma TGF-β levels were significantly and independently associated with lower eGFR in cross-sectional analysis. Doubling of TGF-β was significantly associated with lower eGFR (β estimate after adjusting for CV risk factors = -1.18, 95% CI -2.03, -0.32). We observed no association with albuminuria. There was no association between baseline TGF-β and change in eGFR, but each doubling of TGF-β at baseline was associated with increased risk of a composite outcome of CV events and mortality, adjusted HR 1.10 (95% C.I. 1.02- 1.20, p = 0.006).

CONCLUSION:

In this large cohort of community-dwelling older individuals, high plasma TGF-β levels are modestly, but independently associated with lower eGFR but not with albuminuria in cross-sectional analysis. In addition, TGF-β levels are associated with increased risk of CV events and mortality. Further research is needed to determine the direction of association between plasma TGF-β and the risk of CKD and CKD-associated morbidities in older adults.

KEYWORDS:

CKD; GFR; Older adults; TGF-β

PMID:
28327102
PMCID:
PMC5359982
DOI:
10.1186/s12882-017-0509-6
[Indexed for MEDLINE]
Free PMC Article

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