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Psychiatry Investig. 2017 Mar;14(2):219-225. doi: 10.4306/pi.2017.14.2.219. Epub 2017 Mar 6.

Preliminary Study on Quantitative Sleep EEG Characteristics in Patients with Schizophrenia.

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Department of Psychiatry and Center for Sleep and Chronobiology, Seoul National University Hospital, Seoul, Republic of Korea.
Cooperative Research Centre for Alertness, Safety and Productivity, The University of Sydney, Sydney, Australia.; Sleep and Circadian Group, Woolcock Institute of Medical Research, Glebe, Australia.; School of Physics, The University of Sydney, Sydney, Australia.


We used quantitative electroencephalography (EEG) spectral analysis to compare activity in the bilateral frontal, central, and occipital areas in nine patients with schizophrenia and ten healthy control subjects during standard nocturnal polysomnography. Patients with schizophrenia had longer sleep latency than controls. In N2 sleep, the patients had significantly lower 0.5-1 Hz power and higher theta power in the left frontal region, and higher beta power in the left occipital region than did control subjects. In N3 sleep, the patients with schizophrenia had significantly higher alpha power in the left occipital region than did controls. These findings show distinctive EEG sleep patterns in patients with schizophrenia, which may reflect brain dysfunction or medication effects.


Electroencephalography; Schizophrenia; Sleep

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