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J Cell Sci. 2017 Apr 15;130(8):1347-1353. doi: 10.1242/jcs.199471. Epub 2017 Mar 21.

The tubulin code at a glance.

Author information

1
Institut Curie, PSL Research University, CNRS UMR3348, Orsay F-91405, France.
2
Université Paris Sud, Université Paris-Saclay, CNRS UMR3348, Orsay F-91405, France.
3
Institut Curie, PSL Research University, CNRS UMR3348, Orsay F-91405, France Carsten.Janke@curie.fr.

Abstract

Microtubules are key cytoskeletal elements of all eukaryotic cells and are assembled of evolutionarily conserved α-tubulin-β-tubulin heterodimers. Despite their uniform structure, microtubules fulfill a large diversity of functions. A regulatory mechanism to control the specialization of the microtubule cytoskeleton is the 'tubulin code', which is generated by (i) expression of different α- and β-tubulin isotypes, and by (ii) post-translational modifications of tubulin. In this Cell Science at a Glance article and the accompanying poster, we provide a comprehensive overview of the molecular components of the tubulin code, and discuss the mechanisms by which these components contribute to the generation of functionally specialized microtubules.

KEYWORDS:

Detyrosination; Glutamylation; Glycylation; Tubulin code; Tubulin isotypes

PMID:
28325758
DOI:
10.1242/jcs.199471
[Indexed for MEDLINE]
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