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Environ Pollut. 2017 Jun;225:506-513. doi: 10.1016/j.envpol.2017.03.016. Epub 2017 Mar 18.

Relationships between acrylamide and glycidamide hemoglobin adduct levels and allergy-related outcomes in general US population, NHANES 2005-2006.

Author information

1
Institute of Environmental Health, Department of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
2
Department of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
3
Institute of Environmental Health, Department of Public Health, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: chenguangdi@zju.edu.cn.
4
School of Humanities and Social Sciences, Zhejiang Chinese Medical University, Hangzhou, China. Electronic address: cwm@zju.edu.cn.

Abstract

BACKGROUND:

Acrylamide-induced immunotoxicity and allergic dermatitis have been reported in animal experiments and clinical reports, respectively. However, epidemiological evidence from the general population is limited.

OBJECTIVES:

The purpose of the present study was to estimate the associations between acrylamide exposure and allergy-related outcomes in the general US population.

METHODS:

A total of 6982 subjects were selected from the National Health and Nutrition Examination Survey 2005-2006 (NHANES). Internal exposure was measured by the hemoglobin adducts of acrylamide (HbAA) and its metabolite glycidamide (HbGA). Allergy-related outcomes including asthma, hay fever, allergy, itchy rash, sneeze, wheeze and eczema were obtained by self-administered questionnaires. Allergic sensitization was assessed by the total immunoglobulin E (IgE) levels. The associations of HbAA and HbGA quartiles with allergy-related outcomes were calculated using logistic regression models with multivariable adjustments. Analyses were additionally stratified according to age, gender and serum cotinine levels.

RESULTS:

When setting quartile 1 of HbAA as reference, the odds ratios (ORs) [95% confidence intervals (CIs)] of quartile 2 to 4 for eczema were 1.18 (0.79-1.76), 1.14 (0.73-1.78) and 1.58 (1.14-2.18), respectively (ptrend = 0.002). Individuals at the highest quartile of HbGA had significantly elevated likelihoods of itchy rash (OR = 1.37, 95% CI = 1.02-1.83, ptrend = 0.032) and eczema (OR = 1.45, 95% CI = 1.06-1.97, ptrend = 0.044). The stratification analyses indicated various results in different subgroups.

CONCLUSIONS:

This study indicated significant associations between HbAA and HbGA levels and the likelihoods of allergy-related outcomes in the general US population, depending on age, gender and smoke exposure status. These findings suggested potential public health concerns for the widespread exposure to acrylamide.

KEYWORDS:

Acrylamide; Allergy; Glycidamide; Hemoglobin adducts; NHANES

PMID:
28325597
DOI:
10.1016/j.envpol.2017.03.016
[Indexed for MEDLINE]

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