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3 Biotech. 2014 Feb;4(1):1-12. doi: 10.1007/s13205-013-0121-9. Epub 2013 Feb 19.

Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin.

Author information

1
Department of Biotechnology, M.M.E.C., Maharishi Markandeshwar University, Mullana, Ambala, 133203, Haryana, India.
2
Department of Biological Sciences, R. D. University, Jabalpur, 482001, MP, India.
3
Department of Biotechnology, M.M.E.C., Maharishi Markandeshwar University, Mullana, Ambala, 133203, Haryana, India. anibiotech18@gmail.com.

Abstract

An entomopathogenic fungus, Cordyceps sp. has been known to have numerous pharmacological and therapeutic implications, especially, in terms of human health making it a suitable candidate for ethno-pharmacological use. Main constituent of the extract derived from this fungus comprises a novel bio-metabolite called as Cordycepin (3'deoxyadenosine) which has a very potent anti-cancer, anti-oxidant and anti-inflammatory activities. The current review discusses about the broad spectrum potential of Cordycepin including biological and pharmacological actions in immunological, hepatic, renal, cardiovascular systems as well as an anti-cancer agent. The article also reviews the current efforts to delineate the mechanism of action of Cordycepin in various bio-molecular processes. The study will certainly draw the attention of scientific community to improve the bioactivity and production of Cordycepin for its commercial use in pharmacological and medical fields.

KEYWORDS:

Cordycepin; Cordyceps militaris; Infection; Mechanism; Pharmacological effect

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