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Cancer Immunol Immunother. 2017 May;66(5):667-671. doi: 10.1007/s00262-017-1985-z. Epub 2017 Mar 21.

Exercise and cancer: from "healthy" to "therapeutic"?

Author information

1
Department of Hematology, Center for Cancer Immune Therapy (CCIT), University Hospital Herlev, Herlev Ringvej 75, 2730, Herlev, Denmark.
2
Department of Hematology, Center for Cancer Immune Therapy (CCIT), University Hospital Herlev, Herlev Ringvej 75, 2730, Herlev, Denmark. per.thor.straten@regionh.dk.
3
Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark. per.thor.straten@regionh.dk.

Abstract

Exercise improves functional capacity and patient-reported outcomes across a range of cancer diagnoses. The mechanisms behind this protection have been largely unknown, but exercise-mediated changes in body composition, sex hormone levels, systemic inflammation, and immune cell function have been suggested to play a role. We recently demonstrated that voluntary exercise leads to an influx of immune cells in tumors, and a more than 60% reduction in tumor incidence and growth across several mouse models. Given the common mechanisms of immune cell mobilization in mouse and man during exercise, we hypothesize that this link between exercise and the immune system can be exploited in cancer therapy in particular in combination with immunotherapy. Thus, we believe that exercise may not just be "healthy" but may in fact be therapeutic.

KEYWORDS:

CIMT 2016; Combination treatment; Exercise; Immune cell mobilization; NK cells; Tumor infiltration

PMID:
28324125
PMCID:
PMC5406418
DOI:
10.1007/s00262-017-1985-z
[Indexed for MEDLINE]
Free PMC Article

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