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Endocrinology. 2017 May 1;158(5):1160-1171. doi: 10.1210/en.2016-1250.

Whole-Body Vibration Mimics the Metabolic Effects of Exercise in Male Leptin Receptor-Deficient Mice.

Author information

1
Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
2
Department of Orthopedic Surgery, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
3
Department of Pediatrics, Gastroenterology Division, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
4
Georgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
5
Physiology Department, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
6
Department of Oral Biology, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
7
Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
8
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224.
9
Department of Surgery, Plastic Surgery Division, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.

Abstract

Whole-body vibration (WBV) has gained attention as a potential exercise mimetic, but direct comparisons with the metabolic effects of exercise are scarce. To determine whether WBV recapitulates the metabolic and osteogenic effects of physical activity, we exposed male wild-type (WT) and leptin receptor-deficient (db/db) mice to daily treadmill exercise (TE) or WBV for 3 months. Body weights were analyzed and compared with WT and db/db mice that remained sedentary. Glucose and insulin tolerance testing revealed comparable attenuation of hyperglycemia and insulin resistance in db/db mice following TE or WBV. Both interventions reduced body weight in db/db mice and normalized muscle fiber diameter. TE or WBV also attenuated adipocyte hypertrophy in visceral adipose tissue and reduced hepatic lipid content in db/db mice. Although the effects of leptin receptor deficiency on cortical bone structure were not eliminated by either intervention, exercise and WBV increased circulating levels of osteocalcin in db/db mice. In the context of increased serum osteocalcin, the modest effects of TE and WBV on bone geometry, mineralization, and biomechanics may reflect subtle increases in osteoblast activity in multiple areas of the skeleton. Taken together, these observations indicate that WBV recapitulates the effects of exercise on metabolism in type 2 diabetes.

PMID:
28323991
PMCID:
PMC5460837
DOI:
10.1210/en.2016-1250
[Indexed for MEDLINE]
Free PMC Article

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