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J Clin Endocrinol Metab. 2017 Apr 1;102(4):1350-1357. doi: 10.1210/jc.2017-00022.

Trimester-Specific Urinary Bisphenol A Concentrations and Blood Glucose Levels Among Pregnant Women From a Fertility Clinic.

Author information

1
Departments of Nutrition.
2
Epidemiology.
3
Environmental Health, and.
4
Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115.
5
Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts 02114.
6
Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115.
7
National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30329.

Abstract

Context:

Women with a history of infertility are at increased risk of impaired glucose tolerance during pregnancy. Studies suggest higher urinary bisphenol A (BPA) concentrations are associated with diabetes in nonpregnant populations, but the association between BPA and glucose levels among pregnant women is unclear.

Objective:

To assess trimester-specific urinary BPA concentrations in relation to blood glucose levels among subfertile women.

Design:

Environment and Reproductive Health Study, an ongoing prospective cohort study.

Setting:

A fertility center in a teaching hospital.

Patients:

A total of 245 women contributed at least one urine sample during first and/or second trimesters, delivered a singleton or twin pregnancy, and had available blood glucose data (2005 to 2015).

Main Outcome Measure:

Blood glucose levels after a nonfasting 50-g glucose challenge test at 24 to 28 weeks of gestation.

Results:

The specific gravity-adjusted geometric mean urinary BPA concentrations during first and second trimesters were 1.39 and 1.27 µg/L, respectively. Second-trimester BPA concentrations were positively associated with blood glucose (P, trend = 0.01). Specifically, the adjusted mean glucose levels (95% confidence interval) for women in the highest quartile of second-trimester BPA concentrations was 119 (112, 126) mg/dL compared with 106 (100, 112) mg/dL for women in the lowest quartile. No associations were observed between first-trimester BPA concentrations and glucose levels.

Conclusions:

BPA exposure during the second trimester may have adverse effect on blood glucose levels among subfertile women. As the findings represent the first report suggesting a potential etiologically relevant window for BPA and glucose in humans, further studies are needed.

PMID:
28323984
PMCID:
PMC5460734
DOI:
10.1210/jc.2017-00022
[Indexed for MEDLINE]
Free PMC Article

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