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PLoS One. 2017 Mar 21;12(3):e0174250. doi: 10.1371/journal.pone.0174250. eCollection 2017.

IsoSel: Protein Isoform Selector for phylogenetic reconstructions.

Author information

1
Univ. Lyon, Université Claude Bernard Lyon 1, CNRS, Laboratoire de Biométrie et Biologie Evolutive, UMR 5558, F-69622, Villeurbanne, France.

Abstract

The reliability of molecular phylogenies is strongly dependent on the quality of the assembled datasets. In the case of eukaryotes, the selection of only one protein isoform per genomic locus is mandatory to avoid biases linked to redundancy. Here, we present IsoSel, a tool devoted to the selection of alternative isoforms in the context of phylogenetic reconstruction. It provides a better alternative to the widely used approach consisting in the selection of the longest isoforms and it performs better than Guidance, its only available counterpart. IsoSel is publicly available at http://doua.prabi.fr/software/isosel.

PMID:
28323858
PMCID:
PMC5360266
DOI:
10.1371/journal.pone.0174250
[Indexed for MEDLINE]
Free PMC Article

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