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Gene. 2017 Jun 15;616:1-7. doi: 10.1016/j.gene.2017.03.021. Epub 2017 Mar 18.

The role of miRNA-223 in cancer: Function, diagnosis and therapy.

Author information

1
Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China; Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, United States.
2
Department of Urology, Fujian Medical University Teaching Hospital, Fujian Provincial Hospital, Fuzhou 350001, PR China.
3
Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China. Electronic address: yjinrui2012@163.com.
4
Department of Urology, Fujian Medical University Teaching Hospital, Fujian Provincial Hospital, Fuzhou 350001, PR China. Electronic address: weiyb2008@163.com.

Abstract

MicroRNAs (miRNAs) constitute a large family of small, non-coding RNAs with the capacity to regulate gene expression post-transcriptionally. miRNAs appear to hold promise of mechanistic explanations for various physiological and pathological processes. miRNA-223 is highly conserved and preferentially expressed in the hematopoietic system in regulation of myeloid differentiation. Recently, increasing evidence suggests that miRNA-223 may also play an essential part in both hematological malignancies and solid tumors. miRNA-223 can function as either an oncogene or a tumor suppressor gene, which is achieved by targeting a wide range of genes and regulating downstream signal transduction. As yet, the function of miR-223 in cancer has not been fully characterized and understood. To make it more clear, this review firstly summarizes the present understanding of the regulation of miR-223 at the molecular level, its crucial role in oncogenesis, development, and metastasis, its function as a diagnostic and prognostic biomarker and finally, its potential applications in monitoring and therapy of diverse types of malignancies.

KEYWORDS:

Biological function; Biomarker; Cancer; Oncogene; Oncotherapy; Tumor promoter; miR-223

PMID:
28322994
DOI:
10.1016/j.gene.2017.03.021
[Indexed for MEDLINE]

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