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Eur J Haematol. 2017 Jul;99(1):3-17. doi: 10.1111/ejh.12882. Epub 2017 Apr 25.

A systematic review of health-related quality of life in longitudinal studies of myeloma patients.

Author information

1
Quality of Life Research Centre, Department of Haematology, Odense University Hospital, Odense, Denmark.
2
The Academy of Geriatric Cancer Research (AgeCare), Odense University Hospital, Odense, Denmark.
3
University Hospitals Centre for Health Research, Copenhagen University Hospital, Copenhagen, Denmark.
4
Department of Haematology, Roskilde University Hospital, Roskilde, Denmark.

Abstract

OBJECTIVES:

Multiple myeloma (MM) patients report high symptom burden and reduced health-related quality of life (HRQoL) compared to patients with other haematological malignancies. The aim of this review was to analyse published longitudinal studies including MM patients according to a change in HRQoL scores, which is perceived as beneficial to the patient according to two published guidelines.

METHODS:

A literature search was performed May 2016. Publications with longitudinal follow-up using the EORTC QLQ-C30 instrument for HRQoL measurement of physical functioning, global quality of life, fatigue and/or pain were included. An analysis of mean change from baseline was carried out according to minimal important difference (MID).

RESULTS:

Large and medium HRQoL improvements were reported during first-line treatments. No clinically beneficial change or deteriorations in scores of global QoL or fatigue were reported during relapse treatment. HRQoL data during maintenance therapy are sparse and inconclusive.

CONCLUSIONS:

Guidelines for interpreting changes in HRQoL including definitions of MID have been developed; however, consensus is missing. Improvements in HRQoL are far more likely to occur during first-line compared to relapsed treatment regimens. The background of these findings should be in focus in future studies, and HRQoL measurements should be integrated in maintenance studies.

KEYWORDS:

Health-related quality of life; longitudinal studies; multiple myeloma

PMID:
28322018
DOI:
10.1111/ejh.12882
[Indexed for MEDLINE]

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