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Australas J Dermatol. 2017 Aug;58(3):174-180. doi: 10.1111/ajd.12631. Epub 2017 Mar 20.

Nicotinamide for skin cancer chemoprevention.

Author information

1
Discipline of Dermatology, Central Clinical School, University of Sydney at Royal Prince Alfred Hospital and Melanoma Institute Australia, Sydney, Australia.

Abstract

Nicotinamide (vitamin B3 ) has a range of photoprotective effects in vitro and in vivo; it enhances DNA repair, reduces UV radiation-induced suppression of skin immune responses, modulates inflammatory cytokine production and skin barrier function and restores cellular energy levels after UV exposure. Pharmacological doses of nicotinamide have been shown to reduce actinic keratoses and nonmelanoma skin cancer incidence in high-risk individuals, making this a nontoxic and accessible option for skin cancer chemoprevention in this population.

KEYWORDS:

basal cell carcinoma; melanoma; niacinamide; squamous cell carcinoma; vitamin B3

PMID:
28321860
DOI:
10.1111/ajd.12631
[Indexed for MEDLINE]

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