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Ann Epidemiol. 2017 Apr;27(4):274-280. doi: 10.1016/j.annepidem.2017.02.001. Epub 2017 Feb 21.

Platelet count and total and cause-specific mortality in the Women's Health Initiative.

Author information

1
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY. Electronic address: Geoffrey.kabat@einstein.yu.edu.
2
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.
3
Departments of Medicine and Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY.
4
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
5
MedStar Health Research Institute, Howard University, Washington, DC.

Abstract

PURPOSE:

We used data from the Women's Health Initiative to examine the association of platelet count with total mortality, coronary heart disease (CHD) mortality, cancer mortality, and non-CHD/noncancer mortality.

METHODS:

Platelet count was measured at baseline in 159,746 postmenopausal women and again in year 3 in 75,339 participants. Participants were followed for a median of 15.9 years. Cox proportional hazards models were used to estimate the relative mortality hazards associated with deciles of baseline platelet count and of the mean of baseline + year 3 platelet count.

RESULTS:

Low and high deciles of both baseline and mean platelet count were positively associated with total mortality, CHD mortality, cancer mortality, and non-CHD/noncancer mortality. The association was robust and was not affected by adjustment for a number of potential confounding factors, exclusion of women with comorbidity, or allowance for reverse causality. Low- and high-platelet counts were associated with all four outcomes in never smokers, former smokers, and current smokers.

CONCLUSIONS:

In this large study of postmenopausal women, both low- and high-platelet counts were associated with total and cause-specific mortality.

KEYWORDS:

Cause-specific mortality; Platelet count; Postmenopausal women; Total mortality

PMID:
28320576
DOI:
10.1016/j.annepidem.2017.02.001
[Indexed for MEDLINE]

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