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BMC Nephrol. 2017 Mar 20;18(1):96. doi: 10.1186/s12882-017-0512-y.

Case report - atypical hemolytic uremic syndrome triggered by influenza B.

Author information

1
University Medical Center Hamburg-Eppendorf, Martinistr. 52, D-20246, Hamburg, Germany. r.kobbe@uke.de.
2
University Medical Center Hamburg-Eppendorf, Martinistr. 52, D-20246, Hamburg, Germany.

Abstract

BACKGROUND:

Influenza A infections have been described to cause secondary hemolytic uremic syndrome and to trigger atypical hemolytic uremic syndrome (aHUS) in individuals with an underlying genetic complement dysregulation. To date, influenza B has not been reported to trigger aHUS.

CASE PRESENTATION:

A 6-month-old boy presented with hemolytic uremic syndrome triggered by influenza B infection. Initially the child recovered spontaneously. When he relapsed Eculizumab treatment was initiated, resulting in complete and sustained remission. A pathogenic mutation in membrane cofactor protein (MCP) was detected.

CONCLUSION:

Influenza B is a trigger for aHUS and might be underreported as such. Influenza vaccination may protect patients at risk.

KEYWORDS:

Atypical HUS; HUS; Hemolytic uremic syndrome; Influenza; Influenza vaccination; Quadrivalent; aHUS

PMID:
28320387
PMCID:
PMC5358041
DOI:
10.1186/s12882-017-0512-y
[Indexed for MEDLINE]
Free PMC Article

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