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CNS Neurosci Ther. 2017 Apr;23(4):272-290. doi: 10.1111/cns.12684.

The neuroprotective effects of caffeine in neurodegenerative diseases.

Author information

1
School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, ON, Canada.
2
Muscle Health Research Centre, York University, Toronto, ON, Canada.

Abstract

Caffeine is the most widely used psychostimulant in Western countries, with antioxidant, anti-inflammatory and anti-apoptotic properties. In Alzheimer's disease (AD), caffeine is beneficial in both men and women, in humans and animals. Similar effects of caffeine were observed in men with Parkinson's disease (PD); however, the effect of caffeine in female PD patients is controversial due to caffeine's competition with estrogen for the estrogen-metabolizing enzyme, CYP1A2. Studies conducted in animal models of amyotrophic lateral sclerosis (ALS) showed protective effects of A2A R antagonism. A study found caffeine to be associated with earlier age of onset of Huntington's disease (HD) at intakes >190 mg/d, but studies in animal models have found equivocal results. Caffeine is protective in AD and PD at dosages equivalent to 3-5 mg/kg. However, further research is needed to investigate the effects of caffeine on PD in women. As well, the effects of caffeine in ALS, HD and Machado-Joseph disease need to be further investigated. Caffeine's most salient mechanisms of action relevant to neurodegenerative diseases need to be further explored.

KEYWORDS:

Alzheimer disease; Huntington disease; Parkinson disease; adenosine receptor; amyotrophic lateral sclerosis; caffeine; dosage; neurodegenerative disease; neuroprotection

PMID:
28317317
PMCID:
PMC6492672
DOI:
10.1111/cns.12684
[Indexed for MEDLINE]
Free PMC Article

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