Selective intestinal decontamination of the digestive tract for infection prophylaxis in severely burned patients

W L Manson; A W Westerveld; H J Klasen; E W Sauër

doi:10.3109/02844318709086457

Selective intestinal decontamination of the digestive tract for infection prophylaxis in severely burned patients

Scand J Plast Reconstr Surg Hand Surg. 1987;21(3):269-72. doi: 10.3109/02844318709086457.

Authors

W L Manson¹, A W Westerveld, H J Klasen, E W Sauër

Affiliation

¹ Laboratory for Public Health, Groningen, The Netherlands.

PMID: 2831622
DOI: 10.3109/02844318709086457

Abstract

An oral prophylactic antibiotic regimen aiming at suppression of the gram-negative rods and yeasts of the bowel flora was utilised in 48 severely burned patients to prevent burn wound colonisation. Only 17% of the patients had an actual or potential infection. Only one Pseudomonas infection occurred. The effect of this selective gastro-intestinal decontamination is discussed.

MeSH terms

Adult
Amphotericin B / administration & dosage
Anti-Infective Agents / therapeutic use*
Burns / complications*
Digestive System / microbiology*
Drug Combinations / administration & dosage
Drug Therapy, Combination
Humans
Polymyxins / administration & dosage
Sulfamethoxazole / administration & dosage
Tobramycin / administration & dosage
Trimethoprim / administration & dosage
Trimethoprim, Sulfamethoxazole Drug Combination
Wound Infection / prevention & control*

Substances

Anti-Infective Agents
Drug Combinations
Polymyxins
Amphotericin B
Trimethoprim, Sulfamethoxazole Drug Combination
Trimethoprim
Sulfamethoxazole
Tobramycin