Format

Send to

Choose Destination
J Pediatr Endocrinol Metab. 2017 May 1;30(5):531-541. doi: 10.1515/jpem-2016-0088.

Environmental and genetic determinants of two vitamin D metabolites in healthy Australian children.

Author information

1
Murdoch Childrens Research Institute, Melbourne, Victoria.
2
Department of Endocrinology, Sunshine Hospital, University of Melbourne, Melbourne, Victoria.
3
Menzies Research Institute, University of Tasmania, Hobart, Tasmania.
4
Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Amherst, NY.
5
Department of Paediatrics, University of Melbourne, Melbourne, Victoria.

Abstract

BACKGROUND:

Vitamin D deficiency has been associated with adverse health outcomes. We examined genetic and environmental determinants of serum 25(OH)D3 and 1,25(OH)2D3 in childhood.

METHODS:

The study sample consisted of 322 healthy Australian children (predominantly Caucasians) who provided a venous blood sample. A parental interview was conducted and skin phototype and anthropometry measures were assessed. Concentrations of 25(OH)D3 and 1,25(OH)2D3 were measured by selective solid-phase extraction-capillary liquid chromatography-tandem mass spectrometry. These concentrations were deseasonalised where relevant to remove the effect of month of sampling.

RESULTS:

Deseasonalised log 25(OH)D3 and 1,25(OH)2D3 concentrations were only moderately correlated (r=0.42, p<0.001). The following predicted both 25(OH)D3 and 1,25(OH)2D3: UVR 6 weeks before the interview, natural skin and eye colour, height and vitamin D allelic metabolism score. The following predicted 25(OH)D3 only: lifetime sunburns and vitamin D allelic synthesis score. Overall, 43.5% and 25.6% of variation in 25(OH)D3 and 1,25(OH)2D3 could be explained. After accounting for 25(OH)D3 concentrations, higher UVR 6 weeks before the interview and vitamin D allelic metabolism score further predicted 1,25(OH)2D3 concentrations.

CONCLUSIONS:

Environmental factors and genetic factors contributed to both vitamin D metabolite concentrations. The intriguing finding that the higher ambient UVR contributed to higher 1,25(OH)2D3 after accounting for 25(OH)D3 concentrations requires further evaluation.

KEYWORDS:

1,25-dihydroxyvitamin D3; allelic score; determinants; ultraviolet radiation; vitamin D 25-hydroxyvitamin D3

PMID:
28315849
DOI:
10.1515/jpem-2016-0088
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Sheridan PubFactory
Loading ...
Support Center