Botulinum toxin as an adjunct to monocular recession-resection surgery for large-angle sensory strabismus

J AAPOS. 2017 Apr;21(2):117-120. doi: 10.1016/j.jaapos.2017.03.008. Epub 2017 Mar 16.

Abstract

Purpose: To evaluate the result of using intraoperative botulinum toxin A (BTA) as an adjunct to monocular recession-resection surgery in the management of large-angle sensory strabismus.

Methods: The medical records of patients diagnosed with sensory strabismus with constant large-angle strabismus were reviewed retrospectively to identify those who underwent monocular recession-resection surgery combined with 5 units of BTA injection into the recessed muscle of the nonfixating eye. Surgical outcome was considered successful if the final deviation was within the range of 0Δ-10Δ.

Results: A total of 13 patients (mean age, 31.04 ± 18.5 years) were included, 8 with exotropia and 5 with esotropia. The mean follow-up period was 52.77 ± 10.9 months. The mean preoperative deviation was 66Δ ± 16Δ in the esodeviation group and 56Δ ± 5Δ in the exodeviation group. The final postoperative mean deviation was 6Δ ± 7Δ in the esodeviation group and 6Δ ± 8Δ in the exodeviation group. There were 7 patients (87.5%) with final deviation of ≤10Δ in the exodeviaton group and 4 (80%) in the esodeviation group.

Conclusions: Adjunctive usage of BTA with conventional surgery appears to enhance surgical outcomes by increasing the amount of expected correction. The combined use of BTA with monocular recession-resection rectus muscle surgery may be a good alternative in the treatment of large-angle sensory strabismus with the advantage of less risk of potential complications compared to supramaximal surgery or surgery in the "good" eye.

MeSH terms

  • Adolescent
  • Adult
  • Botulinum Toxins, Type A / administration & dosage*
  • Child
  • Dose-Response Relationship, Drug
  • Eye Movements / drug effects
  • Eye Movements / physiology*
  • Female
  • Follow-Up Studies
  • Humans
  • Injections, Intramuscular
  • Male
  • Middle Aged
  • Neuromuscular Agents / administration & dosage
  • Oculomotor Muscles / drug effects
  • Oculomotor Muscles / surgery*
  • Ophthalmologic Surgical Procedures / methods*
  • Retrospective Studies
  • Strabismus / physiopathology
  • Strabismus / therapy*
  • Treatment Outcome
  • Vision, Binocular / physiology*
  • Visual Acuity
  • Young Adult

Substances

  • Neuromuscular Agents
  • Botulinum Toxins, Type A