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Hum Immunol. 2017 Apr;78(4):325-326. doi: 10.1016/j.humimm.2017.03.007. Epub 2017 Mar 16.

Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 100 Luo infants from the Boro area of Nyanza Province, Kenya.

Author information

1
Division of Vaccine Discovery, La Jolla Institute for Allergy & Immunology (LJI), La Jolla, CA 92037, USA; TBRU-ASTRa, USA.
2
Division of Infectious Diseases and Immunology, New York University School of Medicine, New York, NY 10016, USA.
3
Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia 6150, Australia.
4
Children's Hospital Oakland Research Institute, Oakland, CA, USA.
5
Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia 6150, Australia; Vanderbilt University School of Medicine, Nashville, TN 37235, USA.
6
Aeras, Rockville, MD 20850, USA; TBRU-ASTRa, USA.
7
Division of Infectious Diseases and Immunology, New York University School of Medicine, New York, NY 10016, USA; TBRU-ASTRa, USA. Electronic address: joel.ernst@med.nyu.edu.

Abstract

One hundred healthy infants enrolled as controls in a tuberculosis vaccine study in Nyanza Province, Kenya provided anonymized samples for DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, -DRB1, and -DRB3/4/5 loci. The purpose of the study was to characterize allele frequencies in the local population, to support studies of T cell immunity against pathogens, including Mycobacterium tuberculosis. There are no detectable deviations from Hardy Weinberg proportions for the HLA-B, -C, -DRB1, -DPB1, -DQA1 and -DQB1 loci. A minor deviation was detected at the HLA-A locus due to an excess of HLA-A*02:02, 29:02, 30:02, and 68:02 homozygotes. The genotype data are available in the Allele Frequencies Net Database under identifier 3393.

KEYWORDS:

HLA alleles; Kenya; Luo

PMID:
28315719
PMCID:
PMC5519768
DOI:
10.1016/j.humimm.2017.03.007
[Indexed for MEDLINE]
Free PMC Article

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