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Neuro Endocrinol Lett. 2016 Nov;37(6):461-466.

Network analysis of Urocortins.

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1
Department of Traditional Chinese Medicine, Zhejiang Pharmaceutical College, Ningbo, China.

Abstract

OBJECTIVES:

Urocortins (Ucns), members of corticotropin releasing factor family, play critical roles in a number of pathological and physiological conditions. Many proteins have been reported to participate in Ucns signaling pathways, which formed complex interaction networks.

METHODS:

STITCH ('search tool for interactions of chemicals') is an interaction network database that provides exploration of the known and predicted interactions among large sets of chemicals and proteins.

RESULTS:

In this study, using STITCH, interaction networks of Ucns were constructed by database mining, and then their topological parameters and important nodes were analyzed by network related tools. This may help a quick and thorough overview of the Ucns mechanisms underlying in a visual format.

PMID:
28315631
[Indexed for MEDLINE]
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