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Reprod Toxicol. 2017 Aug;71:166-175. doi: 10.1016/j.reprotox.2017.02.015. Epub 2017 Mar 15.

Hydroxylated polychlorinated biphenyl metabolites (OH-PCBs), maternal smoking and size at birth.

Author information

1
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
2
Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
3
Child Health and Development Studies, Public Health Institute, Berkeley, CA 94709, USA.
4
Department of Toxic Substances Control California Environmental Protection Agency, Berkeley, CA 94710, USA.
5
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA. Electronic address: prf1@cumc.columbia.edu.

Abstract

In a sample of 442 births from the Child Health and Development Studies cohort, we examined associations between maternal prenatal exposure to hydroxylated polychlorinated biphenyl metabolites (OH-PCBs) and pregnancy outcomes, and whether associations were mediated by maternal thyroid hormone levels and/or modified by maternal smoking. Compared to nonsmokers, smokers had twice the mean concentration of 4-OH-CB107 (p<0.001) and lower levels of its parent compound, PCB118 (p=0.001). Among mothers who smoked, the birth weight of newborns with maternal concentrations of 4-OH-CB107 in the upper quartile was 316g lighter (95% confidence interval (CI) 566, 65) compared to those with maternal concentrations in the lowest quartile, after control for PCB118 and other potential confounders. This association was not observed for non-smoking mothers and was not mediated by maternal thyroid hormone levels. Maternal prenatal 4-OH-CB107 levels appear to be influenced by maternal smoking and contribute to lower birth weight among smokers.

KEYWORDS:

Birth outcomes; Birth weight; Gestational length; Hydroxylated PCB metabolites; Maternal smoking; Maternal thyroid hormone; Polychlorinated biphenyls

PMID:
28314564
PMCID:
PMC5513775
DOI:
10.1016/j.reprotox.2017.02.015
[Indexed for MEDLINE]
Free PMC Article

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