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Curr Opin Cell Biol. 2017 Apr;45:55-61. doi: 10.1016/j.ceb.2017.02.009. Epub 2017 Mar 15.

Non-autonomous cell proliferation in the mammary gland and cancer.

Author information

1
Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, United States; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco, 600 16th Street, Room 522, San Francisco, California 94158, United States; Medical Scientist Training Program, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, United States.
2
UC Berkeley-UCSF Group in Bioengineering, 1700 Fourth Street, Room 216, San Francisco, California 94158, United States; UCSF Bioengineering and Therapeutic Sciences, 1700 Fourth Street, Room 216B, San Francisco, California 94158, United States.
3
Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, United States; UC Berkeley-UCSF Group in Bioengineering, 1700 Fourth Street, Room 216, San Francisco, California 94158, United States; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco, 600 16th Street, Room 522, San Francisco, California 94158, United States. Electronic address: zev.gartner@ucsf.edu.

Abstract

Cells decide whether to grow and divide by integrating internal and external signals. Non-autonomous cell growth and proliferation occurs when microenvironmental signals from neighboring cells, both physical and secreted, license this decision. Understanding these processes is vital to developing an accurate framework for cell-cell interactions and cellular decision-making, and is useful for advancing new therapeutic strategies to prevent dysregulated growth. Here, we review some recent examples of non-autonomous cell growth in the mammary gland and tumor cell proliferation.

PMID:
28314237
DOI:
10.1016/j.ceb.2017.02.009
[Indexed for MEDLINE]

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