Use of hepatobiliary phase images in Gd-EOB-DTPA-enhanced MRI of breast cancer hepatic metastasis to predict response to chemotherapy

Clin Imaging. 2017 May-Jun:43:127-131. doi: 10.1016/j.clinimag.2017.03.005. Epub 2017 Mar 9.

Abstract

Objectives: To determine the prognostic value of Gd-EOB-DTPA MRI findings of liver metastasis from breast cancer.

Methods: 29 metastatic lesions from 12 breast cancer patients who received chemotherapy were retrospectively reviewed. We evaluated hepatobiliary phase of the lesions and classified them as a "target" or "non-target" appearance. The relationship of appearance or SI ratio with tumor response was analyzed.

Results: A non-target appearance was more frequent in disease control group than in non-control group [14/18 (77.8%) vs. 4/18 (22.2%)], and it was associated with a better response [p=0.048].

Conclusion: HBP analysis may be useful to predict the response to chemotherapy and survival.

Keywords: Breast cancer liver metastases; Chemotherapy response; Gadoxetic acid; Hepatobiliary phase (HBP); MRI.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Agents / therapeutic use
  • Biliary Tract / diagnostic imaging*
  • Biliary Tract / pathology
  • Breast Neoplasms / diagnosis
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / pathology*
  • Contrast Media*
  • Female
  • Gadolinium
  • Gadolinium DTPA*
  • Humans
  • Liver / diagnostic imaging*
  • Liver / pathology
  • Liver Neoplasms / diagnostic imaging
  • Liver Neoplasms / drug therapy
  • Liver Neoplasms / secondary*
  • Magnetic Resonance Imaging / methods*
  • Middle Aged
  • Prognosis
  • Reproducibility of Results
  • Retrospective Studies
  • Treatment Outcome

Substances

  • Antineoplastic Agents
  • Contrast Media
  • gadolinium ethoxybenzyl DTPA
  • Gadolinium
  • Gadolinium DTPA