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  • PMID: 28314117 was deleted because it is a duplicate of PMID: 28520521
SLAS Discov. 2017 Jun;22(5):456-472. doi: 10.1177/1087057117696795.

Three-Dimensional Cell Cultures in Drug Discovery and Development.

Author information

1
1 Biochemical Technologies, Corning Research and Development Corporation, Corning Incorporated, Corning, NY, USA.
2
2 Corning Life Sciences, Corning Incorporated, Tewksbury, MA, USA.

Abstract

The past decades have witnessed significant efforts toward the development of three-dimensional (3D) cell cultures as systems that better mimic in vivo physiology. Today, 3D cell cultures are emerging, not only as a new tool in early drug discovery but also as potential therapeutics to treat disease. In this review, we assess leading 3D cell culture technologies and their impact on drug discovery, including spheroids, organoids, scaffolds, hydrogels, organs-on-chips, and 3D bioprinting. We also discuss the implementation of these technologies in compound identification, screening, and development, ranging from disease modeling to assessment of efficacy and safety profiles.

KEYWORDS:

3D bioprinting; 3D cell culture; disease models; efficacy; multicellular spheroid; organoids; organs-on-chips; safety; screening; toxicity

PMID:
28520521
PMCID:
PMC5448717
DOI:
10.1177/1087057117696795
[Indexed for MEDLINE]

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