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Chem Commun (Camb). 2017 Mar 28;53(26):3673-3676. doi: 10.1039/c7cc01459g.

Illuminating cytochrome P450 binding: Ru(ii)-caged inhibitors of CYP17A1.

Author information

1
Department of Chemistry, Wayne State University, Detroit, MI 48202, USA. jkodanko@chem.wayne.edu.
2
Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.
3
Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA.
4
Department of Pharmacology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA.
5
Department of Chemistry, Binghamton University, Binghamton, New York 13902, USA.
6
Department of Pharmacology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA and Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA.
7
Department of Chemistry, Wayne State University, Detroit, MI 48202, USA. jkodanko@chem.wayne.edu and Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA.

Abstract

New Ru(ii)-caged abiraterone complexes were synthesized that exhibit strong absorption in the visible region and release the steroidal CYP17A1 inhibitor abiraterone upon exposure to low energy visible light in buffer and prostate cancer cells. Photoinduced release results in abiraterone binding to its CYP17A1 target in an inhibitory mode.

PMID:
28304025
PMCID:
PMC5468790
DOI:
10.1039/c7cc01459g
[Indexed for MEDLINE]
Free PMC Article

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